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Sexual dysfunction that continued after discontinuation of treatmentincluding erectile dysfunctionlibido disordersejaculation disordersand orgasm disordersmale infertility and/or poor seminal qualitynormalization or improvement of seminal quality has been reported after discontinuation of finasteridetesticular painSee Clinical Trials Experience
Although the cancer risk appears to be lowthe FDA distributed the announcement to inform doctors and patients of safety revisions to the warning and precaution labels for this class of drugsEvidence of the increased risk comes from two large clinical trialsthe seven-year Prostate Cancer Prevention TrialPCPTand the four-year Reduction by Dutasteride of Prostate Cancer EventsREDUCEtrial.
In men with male pattern hair lossandrogenetic alopeciathe balding scalp contains miniaturized hair follicles and increased amounts of DHT compared with hairy scalpAdministration of finasteride decreases scalp and serum DHT concentrations in these menThe relative contributions of these reductions to the treatment effect of finasteride have not been definedBy this mechanismfinasteride appears to interrupt a key factor in the development of androgenetic alopecia in those patients genetically predisposed.
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